A primer on noise-induced transitions in applied dynamical systems

Noise plays a fundamental role in a wide variety of physical and biological dynamical systems. It can arise from an external forcing or due to random dynamics internal to the system. It is well established that even weak noise can result in large behavioral changes such as transitions between or escapes from quasi-stable states. These transitions can correspond to critical events such as failures or extinctions that make them essential phenomena to understand and quantify, despite the fact that their occurrence is rare. This article will provide an overview of the theory underlying the dynamics of rare events for stochastic models along with some example applications

The Geographically Contiguous and Expanding Coastal Range of the Northern Curlytail Lizard (Leiocephalus carinatus armouri ) in Florida

We surveyed for the presence of the Northern Curlytail Lizard, Leiocephalus carinatus armouri, from Port Salerno, Martin County, FL, northward to the Indian River-Brevard county line to determine the extent to which this species occurs along the Florida East Coast. The geographic range of L. c. armouri appears to be uninterrupted along the coast from northern Broward County through Palm Beach County. The heavily modified coastal habitat provided this species with the open sunny conditions and cement analogues to the rocky substratum to which it is adapted. Its ubiquity, rate of geographic expansion, combined with its carnivorous habits and large body size, have long since set the stage for an extensive restructuring of the indigenous and exotic lizard fauna in a way that has not been seen since its initial establishment in Palm Beach County almost one-half century ago. Urban heat island effects notwithstanding, frost isotherms predict instability of populations north of Fort Pierce and just below Sarasota on the West Coast

The Cranberry Flavonoids PAC DP-9 and Quercetin Aglycone Induce Cytotoxicity and Cell Cycle Arrest and Increase Cisplatin Sensitivity in Ovarian Cancer Cells

Cranberry flavonoids (flavonols and flavan-3-ols), in addition to their antioxidant properties, have been shown to possess potential in vitro activity against several cancers. However, the difficulty of isolating cranberry compounds has largely limited anticancer research to crude fractions without well-defined compound composition. In this study, individual cranberry flavonoids were isolated to the highest purity achieved so far using gravity and high performance column chromatography and LC-MS characterization. MTS assay indicated differential cell viability reduction of SKOV-3 and OVCAR-8 ovarian cancer cells treated with individual cranberry flavonoids. Treatment with quercetin aglycone and PAC DP-9, which exhibited the strongest activity, induced apoptosis, led to caspase-3 activation and PARP deactivation, and increased sensitivity to cisplatin. Furthermore, immunofluorescence microscopy and western blot study revealed reduced expression and activation of epidermal growth factor receptor (EGFR) in PAC DP-9 treated SKOV-3 cells. In addition, quercetin aglycone and PAC DP-9 deactivated MAPK-ERK pathway, induced downregulation of cyclin D1, DNA-PK, phospho-histone H3 and upregulation of p21, and arrested cell cycle progression. Overall, this study demonstrates promising in vitro cytotoxic and anti-proliferative properties of two newly characterized cranberry flavonoids, quercetin aglycone and PAC DP-9, against ovarian cancer cells